TNF alpha, a proinflammatory cytokine with multiple functions, is part of the tumor necrosis factors (TNF) superfamily. This cytokine is mostly secreted by macrophages and binds to its receptors, the TNFRSF1A/TNFR1B/TNFBR. TNF alpha plays a role in cell proliferation, differentiation, immune cells, lipid metabolism, coagulation, and the regulation of immune cells.
TNF alpha is a multimer consisting of 2-3, 3 or 5 noncovalently linked units. However, it shows a single 17kDa band after SDS-PAGE under non reducing conditions. Knockout studies in mice suggested that TNF alpha has neuroprotective properties. You can know more about an anti-TNF alpha antibody via online sources.
TNF alpha was found to cause tumor necrosis when injected to tumor-bearing mice. TNF-alpha also plays a role in the immune system's response to certain viral, parasitic, and bacterial infections. It is also responsible for necrosis specific tumors. TNF-alpha is synergistic to interferon-gamma and causes cytolysis of certain cells.
This cytokine has been implicated with a number of diseases including cancer, diabetes resistance, and autoimmune diseases. Mouse TNF-alpha antibody recognizes mouse Tumour necrosis Factor alpha (TNF alpha), a 17.3kDa multifunctional pro-inflammatory cytokine that is primarily produced by macrophages but also by T and T lymphocytes, activated monocytes and fibroblasts.
TNF-alpha is available in both a mature soluble and transmembrane form. It has many biological properties including activation and NF-KappaB activation, induction of apoptosis and stimulation of cell differentiation under certain conditions.